Proteins - Purified Proteins, Heat Shock Proteins, Oxidative Cellular Stress

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Product Name: Recombinant Human Cpn10
Catalog #: SPR-310A
Package size: 50ug
Price: $195.00 USD

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Alternate Product Sizes: SPR-310B, SPR-310C
Type: Recombinant Protein
Conjugate/Tag: No tags
Datasheet: SPR 310 Chaperonin 10 (Cpn10) Heat Shock
Description: Cpn10 Protein
Research Area: Chaperones, Heat Shock
Alternative Names: 10kDa Chaperonin, Chaperonin 10, Cpn 10, EPF, GROES, Heat Shock 10kD protein1, Hsp10, HSPE1
Species: Human
Applications: WB Control
Accession Number: NM_002157.2
Gene ID: 3336
SwissProt: P61604
Expression System: E. coli
Background Info: Molecular weight of approximately 10kDa
Form: Multi-Step Chromatography
Storage Buffer: 20mM Tris, pH 7.5, 0.3M NaCl, 10% glycerol, 1mM DTT
Concentration: 0.9mg/mL
Certificate of Analysis: This product has been certified >90% pure using SDS-PAGE analysis.
Storage Temp: -20°C
Shipping Temp: Dry Ice, Blue Ice or 4°C

SDS PAGE of native human Cpn10.

Research Background: Chaperonin 10, otherwise known as Cpn10, (groES in E.coli) make up a family of small heart shock proteins with an approximate molecular mass of 10kDa (Hsp10s). Cpn10 acts as a co-chaperone and interacts with the Hsp60 family to promote proper folding of polypeptides. Cpn10 and Cpn60 both exhibit sevenfold axis of symmetry and function as a team in the protein folding and assembly process (1). Cpn10 has been located in human platelets, but is also present in human maternal serum (2, 3). It has been reported that human Cpn10 is identical with early pregnancy factor, which is involved in control over cell growth and development. This identification suggest that Cpn10 may act like a hormone in stressful situations such as pregnancy (4).
References: 1. Velez-Granell C.S., et al. (1994) J of Cell Science. 107(3):539-549.
2. Morton H., Hegh V., and Clunie G.J.A. (1974) Nature (London) 249: 459-460.
3. Cavanagh A.C., and Morton H. (1994) Eur. J. Biochem. 222: 551-560.
4. Minto M., et al. (1998) Molecular Cell Research. 1403 (2): 151-157.

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