Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Cyclosporine
Catalog #: SIH-201-50MG
Size: 50mg
Price: $575.00 USD

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Alternate Product Sizes: SIH-201-10MG
Type: Inhibitor
Datasheet: SIH 201 Cyclosporine Apoptosis Inhibitor
Description: Inhibits mitochondrial permeability pore opening
Research Area: Apoptosis
Alternative Names: Cyclosporin A
CAS Number: 59865-13-3
Formula: C62H111N11O12
Molecular weight: 1202.63
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in DMSO, 50mM in ethanol.
Appearance: White Solid
Safety Phrases: Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases:
R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R45 - May cause cancer
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects

Hazard Phrases:
H302-H350-H360

Precautionary Phrases:
P201-P308 + P313
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C

Structure of Cyclosporin A

Research Background: Cyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
References: 1. Heitman J., et al. (1992) New Biol. 4:448.
2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.

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