Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Cyclopamine
Catalog #: SIH-226-5MG
Size: 5mg
Price: $355.00 USD

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Alternate Product Sizes: SIH-226-1MG
Type: Inducer
Datasheet: SIH 226 Cyclopamine Apoptosis Inducer
Description: Inhibits hedgehog signaling
Research Area: Apoptosis
CAS Number: 4449-51-8
Formula: C27H41NO2
Molecular weight: 411.6
Source/Host: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble to 5mM in ethanol.
Appearance: White Solid
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases:
R62- Possible risk of impaired fertility
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C

Structure of Cyclopamine

Research Background: Cyclopamine is a hedgehog signaling pathway inhibitor that influences the balance between the active and inactive forms of the Smoothened protein (1). It is being investigated as a treatment agent in basal cell carcinoma, medulloblastoma and rhabdomyosarcoma (1, 2).
References: 1. Beachy P.A., et al. (2000) Nature. 406(6799): 1005-1009.
2. Yauch R.L., et al. (2009) Science. 326(5952): 572-574.

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