Small Molecules - Apoptosis, Cellular Oxidative Stress,

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Product Name: Valinomycin
Catalog #: SIH-230-10MG
Size: 10mg
Price: $42.00 USD

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Alternate Product Sizes: SIH-230-50MG
Type: Inducer
Datasheet: SIH 230 Valincomycin Apoptosis Inducer
Description: Induces loss of mitochondrial membrane potential
Research Area: Apoptosis
CAS Number: 2001-95-8
Formula: C54H90N6O18
Molecular weight: 1111.32
Source/Host: Synthetic
Purity: >98%
Solubility: Soluble to 25mM in DMSOand 25mM in ethanol.
Appearance: White Solid
Safety Phrases: Classification: Very Toxic. May be fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R68 - Possible risk of irreversible effects

Hazard Phrases:
H300-H310

Precautionary Phrases:
P264-P280-P302 + P350-P310
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C

Structure of Valinomycin

Research Background: Valinomycin is a dodecadepsipeptide, and a member of a group of natural neutral ionophores. It is highly selective for potassium ions within the cell membrane (1). It functions as a potassium-specific transporter and facilitates the movement of potassium ions through lipid membranes down an electrochemical potential gradient (2).
References: 1. Lars R., Jenkins A.T.A. (2007) Bioelectrochem. 70(2): 387-393.
2. Cammann K. (1985) Top Curr Chem. 128: 219-258.

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