Small Molecules - Apoptosis, Cellular Oxidative Stress,

Home > Products > Small Molecules > SIH-301-50MG

Product Name: A-967079
Catalog #: SIH-301-50MG
Size: 50mg
Price: $369.00 USD

Add to Cart

Bulk Quote
Alternate Product Sizes: SIH-301-10MG
Type: Inhibitor
Datasheet: SIH 301 A 967079 Ion Channel Inhibitor
Description: TRPA1 blocker
Research Area: Ion Channels
Formula: C12H14FNO
Molecular weight: 207.3
Source/Host: Synthetic
Purity: >99%
Solubility: DMSO (25mg/ml)
Appearance: White solid
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Phrases:
H302-H315-H317-H318-H335

Precautionary Phrases:
P261-P280-P305 + P351 + P338
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C

Structure of A-967079

Research Background: A-967079 is a TRPA1 antagonist (1) and cell permeable. It has been found to be a potent blocker of TRPA1 channels. It is an oxime analogue and resembles AP18 from a structural perspective, although it has a methyl addition and a chlorine–ﬂuorine substitution. However, compared with AP18 and HC-030031, A-967079 is signiﬁcantly more potent (100-fold on human and 24-fold on rat TRPA1) and has a much improved pharmacokinetic proﬁle. A-967079 is also more selective, with >1000-fold selectivity over other TRP channels and >150-fold selectivity over 75 other tested proteins (2).
References: 1. McGaraughty S., et al. (2010) Mol Pain. 6: 14. jun Chen et al. (2011) PAIN 152: 1165–1173

Full Name:	*
Company:	*
Phone:	*
Email:	*
Address:	*
Address 2:
City:	*
State/Province:
Country:	*
Zip/Postal:	*
Primary Work Interest:	*
Send Print Catalog?	* Yes No
Newsletter Sign-Up:	Cellular Stress Oxidative Stress Ion Channels & Transporters Apoptosis
Check box before sending form:	*