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| Product Name | BIX-01294 |
| Description |
HMT inhibitor |
| Purity | >98% |
| CAS No. | 935693-62-2 |
| Molecular Formula | C28H38N6O2*3HCl |
| Molecular Weight | 600.02 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (100 mM) or Water (100 mM) |
| Source | Synthetic |
| Appearance | Cream solid |
| SMILES | CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl |
| InChI | InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31) |
| InChIKey | OSXFATOLZGZLSK-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | BIX-01294 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-347) |
Biological Description
| Alternative Names | 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 25150857 |
| Scientific Background | G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. |
| References |
1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317. |
Product Images
Chemical structure of BIX-01294 (SIH-347), a Histone methyltransferase inhibitor. CAS #: 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl. Molecular Weight: 600.02 g/mol.
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