Discovery through Partnership | Excellence through Quality
| Product Name | Chaetocin |
| Description |
Methyltransferase inhibitor |
| Purity | >99% (TLC), NMR conforms |
| CAS No. | 28097-03-2 |
| Molecular Formula | C30H28N6O6S4 |
| Molecular Weight | 696.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Lyophilized Solid |
| InChI | InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40 |
| InChIKey | PZPPOCZWRGNKIR-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful- Harmful by inhalation, in contact with skin, and if swallowed. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312- IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P304+P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. Hazard Statements: H302- Harmful if swallowed H312- Harmful in contact with skin H332- Harmful if inhaled |
| Cite This Product | Chaetocin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-351) |
Biological Description
| Alternative Names | 2,2',3S,3'S,5aR,5'aR,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10bR,10'bR(11aS,11'aS)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 161591 |
| Scientific Background | Inhibits the lysine methyltransferase SU (VAR)3-9. Displays antimyeloma activity in IL-6-dependent myeloma cell lines. Cell permeable. |
| References |
1. Greiner D., et al. (2005) Nat Chem Biol. 1: 143. 2. Isham, C.R., et al. (2007) Blood. 109: 2579. |
Product Images
Chemical structure of Chaetocin (SIH-351), a Lys methyltransferase inhibitor. CAS #: 28097-03-2 . Molecular Formula: C30H28N6O6S4. Molecular Weight: 696.9 g/mol.
Powered by Bioz
StressMarq Biosciences :
Based on validation through cited publications.