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| Product Name | Decitabine |
| Description |
DNA hypomethylation agent |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 2353-33-5 |
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O |
| InChI | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| Safety Phrases |
Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341 – Suspected of causing genetic defects H360 – May damage fertility or the unborn child Precautionary Statements: P280 – Wear protective gloves/protective clothing/ eye protection/ face protection P308+313 – If exposed or concerned: Get Medical Advise/Attention |
| Cite This Product | Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352) |
Biological Description
| Alternative Names | 5-Aza-2’-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 451668 |
| Scientific Background | Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable. |
| References |
1. Bender C.M., et al. (1998) Cancer Res. 58: 95. 2. El-Serafi A.T., et al. (2011) Differentiation 81: 35. |
Product Images
Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol.
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