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| Product Name | Nonactin |
| Description |
Ammonium ionophore |
| Purity | >98% (TLC) |
| CAS No. | 6833-84-7 |
| Molecular Formula | C40H64O12 |
| Molecular Weight | 736.93 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water. |
| Source | Synthetic |
| Appearance | White to off-White solid |
| SMILES | C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C |
| InChI | InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1- |
| InChIKey | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| Safety Phrases |
Classification: Toxic. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation. Precautionary Phrases: P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P280 - Wear protective gloves/protective clothing. P305+P351+P338 – IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 – Store locked up. P501 – Dispose of contents/container in accordance with local/regional/national/international regulations. |
| Cite This Product | Nonactin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-372) |
Biological Description
| Alternative Names | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20¬R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-O¬ctamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo-[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,3¬0-tetrone |
| Research Areas | Neuroscience |
| PubChem ID | 72519 |
| Scientific Background | Nonactin also known as Polynanctin, Werramycin A is a member of the family of cyclic ionophores. It has a high selectivity for ammonium ions and for this reason is also known as “ammonium ionophore”. It was first isolated by Corbaz et al. in 1955 from bacterial strains (1). To understand the required stereochemistry for an efficient bacterial and ion binding, various isothermal calorimetric measurements were performed with K+, Na+ and NH4+. Nonactin is active against a range of gram positive organisms and has a high selectivity for K+ (2). |
| References |
1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48. 2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165. |
Product Images
Chemical structure of Nonactin (SIH-372), a Ammonium ionophore. CAS #: 6833-84-7. Molecular Formula: C40H64O12. Molecular Weight: 736.93 g/mol.
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