24(S)-Hydroxycholesterol

Name: 24(S)-Hydroxycholesterol
SKU: SIH-384
Availability: InStock

LXR ligand

Catalog No. SIH-384

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CAS No.	474-73-7
Molecular Formula	C27H46O2

SKU: SIH-384 Categories: Ligand, Small Molecules

Product Name	24(S)-Hydroxycholesterol
Description	LXR ligand
Purity	>98%
CAS No.	474-73-7
Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.7
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Ligand
Solubility	Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C).
Source	Synthetic
Appearance	White solid
SMILES	[C@]24([C@H]([C@@H]1CC=C3[C@@]([C@H]1CC2)(CC[C@H](O)C3)C)CC[C@@H]4[C@@H](CC[C@@H](C(C)C)O)C)C
InChI	InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
InChIKey	IOWMKBFJCNLRTC-XWXSNNQWSA-N
Safety Phrases	Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
Cite This Product	24(S)-Hydroxycholesterol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-384)

Alternative Names	(3β,24S)-Cholest-5-ene-3,24-diol
Research Areas	Cell Signaling
PubChem ID	121948
Scientific Background	Endogenous agonist for the nuclear receptor LXR. Important metabolite of cholesterol in the brain. Displays neurotoxic effects on human neuroblastoma cells. Cerebrospinal fluid concentrations of 24(S)-hydroxycholesterol are increased in patients with Alzheimer’s disease and mild cognitive impairment.
References	1. Chawla A., et al. (2001) Science. 294(5548): 1866-70. 2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804. 3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5. 4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5. 5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.

Chemical structure of 24(S)-Hydroxycholesterol (SIH-384), a LXR ligand. CAS #: 474-73-7. Molecular Formula: C27H46O2 . Molecular Weight: 402.7 g/mol.

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