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| Product Name | Bafilomycin A1 |
| Description |
Autophagy inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 88899-55-2 |
| Molecular Formula | C35H58O9 |
| Molecular Weight | 622.84 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50mg/mL) |
| Source | Synthetic |
| Appearance | White powder to colorless film. |
| SMILES | [C@]1(O[C@@H]([C@H]([C@H](O)C1)C)C(C)C)(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)C(=C/C(=C/[C@H]([C@@H](O)[C@H](CC(=C/C=C/[C@@H]2OC) |
| InChI | InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H |
| InChIKey | XDHNQDDQEHDUTM-JQWOJBOSSA-N |
| Safety Phrases |
Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Bafilomycin A1 (StressMarq Biosciences, Canada, Cat # SIH-391) |
Biological Description
| Alternative Names | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 6436223 |
| Scientific Background | Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation. |
| References |
1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212. 2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16. 3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42. |
Product Images
Chemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol.
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StressMarq Biosciences :
Based on validation through cited publications.
Eric Wang :
We ordered this inhibitor and utilized 100 nm to pre-treat differentiated THP-1 cells for 1 h before incubating with autophagy inducer. We showed that this inhibitor can efficiently inhibit the autophagy flux by measuring the level of LC3-II. We recommend it.