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| Product Name | PHA 665752 |
| Description |
MET kinase inhibitor |
| Purity | >98% |
| CAS No. | 477575-56-7 |
| Molecular Formula | C32H34Cl2N4O4S |
| Molecular Weight | 641.61 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO. |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | ClC1=C(C(=CC=C1)Cl)C[S](=O)(=O)C3=CC=C2NC(C(/C2=C3)=CC4=C(C(=C([NH]4)C)C(=O)N5CCC[C@@H]5CN6CCCC6)C)=O |
| InChI | InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,1 |
| InChIKey | OYONTEXKYJZFHA-SSHUPFPWSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | PHA 665752 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-421) |
Biological Description
| Alternative Names | (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 10461815 |
| Scientific Background | PHA 665752 is a potent and selective MET kinase, ATP-competitive inhibitor. It has been studied as an antitumor agent because it has been seen to inhibit tumorigenicity and angiogenesis in mouse lung cancer xenografts. |
| References | 1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34. |
Product Images
Chemical structure of PHA 665752 (SIH-421), a MET kinase inhibitor. CAS #: 477575-56-7. Molecular Formula: C32H34Cl2N4O4S. Molecular Weight: 641.61 g/mol.
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