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| Product Name | Alsterpaullone |
| Description |
CDK, GSK Inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 237430-03-4 |
| Molecular Formula | C16H11N3O3 |
| Molecular Weight | 293.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO; insoluble in water or 100% ethanol |
| Source | Synthetic |
| Appearance | Yellow to brown powder |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-] |
| InChI | InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20) |
| InChIKey | OLUKILHGKRVDCT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well - ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Alsterpaullone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-431) |
Biological Description
| Alternative Names | 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5005498 |
| Scientific Background | Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable. |
| References |
1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569. 2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194. 3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919. |
Product Images
Chemical structure of Alsterpaullone (SIH-431), a GSK3beta kinase inhibitor, CDK5/p25 inhibitor. CAS #: 237430-03-4. Molecular Formula: C16H11N3O3. Molecular Weight: 293.3 g/mol.
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