BAY 11 7082

Name: BAY 11 7082
SKU: SIH-434
Availability: InStock

IKK kinase inhibitor

Catalog No. SIH-434

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CAS No.	19542-67-7
Molecular Formula	C10H9NO2S

SKU: SIH-434 Categories: Inhibitor, Small Molecules

Product Name	BAY 11 7082
Description	IKK kinase inhibitor
Purity	>98% (HPLC)
CAS No.	19542-67-7
Molecular Formula	C₁₀H₉NO₂S
Molecular Weight	207.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 25 mM in ethanol and to 100 mM in DMSO
Source	Synthetic
Appearance	White solid
SMILES	C1=C([S](=O)(=O)C=CC#N)C=CC(=C1)C
InChI	InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChIKey	DOEWDSDBFRHVAP-KRXBUXKQSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	BAY 11 7082 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-434)

Alternative Names	Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	5353431
Scientific Background	BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
References	1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.

Chemical structure of BAY 11 7082 (SIH-434), a IKK kinase inhibitor. CAS #: 19542-67-7. Molecular Formula: C10H9NO2S. Molecular Weight: 207.3 g/mol.

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