BML 277

Name: BML 277
SKU: SIH-436
Availability: InStock

CHK2 kinase inhibitor

Catalog No. SIH-436

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CAS No.	516480-79-8
Molecular Formula	C20H14ClN3O2

SKU: SIH-436 Categories: Inhibitor, Small Molecules

Product Name	BML 277
Description	CHK2 kinase inhibitor
Purity	>98% (TLC)
CAS No.	516480-79-8
Molecular Formula	C₂₀H₁₄ClN₃O₂
Molecular Weight	363.8
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml)
Source	Synthetic
Appearance	Off-white solid
SMILES	C1=CC(=CC=C1C2=NC3=C(N2)C=CC(=C3)C(=O)N)OC4=CC=C(C=C4)Cl
InChI	InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChIKey	UXGJAOIJSROTTN-UHFFFAOYSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	Bml 277 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-436)

Alternative Names	Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	9969021
Scientific Background	Bml 277 is a highly selective inhibitor of Chk2, making it a useful tool for dissecting the role of Chk2 in cellular signaling.
References	1. Pereg Y., et al. (2006) Mol. Cell Biol. 26(18): 6819–6831.

Chemical structure of BML 277 (SIH-436), a CHK2 kinase inhibitor. CAS #: 516480-79-8. Molecular Formula: C20H14ClN3O2. Molecular Weight: 363.8 g/mol.

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