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| Product Name | Dasatinib |
| Description |
Kinase inhibitor |
| Purity | >98% |
| CAS No. | 302962-49-8 |
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | 488.0 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ) |
| Source | Synthetic |
| Appearance | Crystalline solid |
| SMILES | C1=C(SC(=N1)NC2=CC(=NC(=N2)C)N3CCN(CC3)CCO)C(=O)NC4=C(C=CC=C4Cl)C |
| InChI | InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) |
| InChIKey | ZBNZXTGUTAYRHI-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute Toxicity: Oral, Category 3 Toxic To Reproduction, Category 1B Target Organ Systemic Toxicity (single exposure), Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301: Toxic if swallowed. H360: May damage fertility or the unborn child. H370: Causes damage to organs {uterus, testicles,ovaries}. H373: May cause damage to {uterus, testicles,ovaries} through prolonged or repeated exposure. Precautionary statements: P264: Wash {hands} thoroughly after handling. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P308+313: IF exposed or concerned: Get medical attentiodvice. P312: Call a {POISON CENTER/doctor/...} if you feel unwell. P314: Get medical attentiodvice if you feel unwell. |
| Cite This Product | Dasatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-440) |
Biological Description
| Alternative Names | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 3062316 |
| Scientific Background | Dasatinib is a dual Src and Abl kinase inhibitor with ∼325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner. |
| References | 1. Benjamini O., et al. (2014) Am. J. Hematology. 89(3): 282–287. |
Product Images
Chemical structure of Dasatinib (SIH-440), a Src and Bcr/Abl kinase inhibitor. CAS #: 302962-49-8. Molecular Formula: C22H26ClN7O2S. Molecular Weight: 488 g/mol.
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