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| Product Name | Erlotinib Hydrochloride |
| Description |
EGFR Kinase inhibitor |
| Purity | >99% |
| CAS No. | 183319-69-9 |
| Molecular Formula | C22H24ClN3O4 |
| Molecular Weight | 429.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO at 18 mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility |
| Source | Synthetic |
| Appearance | Solid powder |
| SMILES | [H+].C1=C(OCCOC)C(=CC2=NC=NC(=C12)NC3=CC(=CC=C3)C#C)OCCOC.[Cl-] |
| InChI | InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H |
| InChIKey | GTTBEUCJPZQMDZ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Erlotinib Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-444) |
Biological Description
| Alternative Names | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 176871 |
| Scientific Background | Erlotinib Hydrochloride inhibits the human epidermal growth factor receptor (HER-1/EGFR) tyrosine kinase. |
| References | 1. Ali S., et al. (2008) Mol. Cancer Ther. 7(6): 1708–1719. |
Product Images
Chemical structure of Erlotinib Hydrochloride (SIH-444), a EGFR Kinase inhibitor. CAS #: 183319-69-9. Molecular Formula: C22H24ClN3O4. Molecular Weight: 429.9 g/mol.
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