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| Product Name | Gefitinib |
| Description |
EGFR Kinase inhibitor |
| Purity | >99% |
| CAS No. | 184475-35-2 |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (89 mg/ml at 25 °C), methanol (20 mg/ml), ethanol (4 mg/ml at 25 °C), DMF (20 mg/ml), and water (<1 mg/ml at 25 °C) |
| Source | Synthetic |
| Appearance | Solid |
| SMILES | C1=C3C(=CC(=C1OC)OCCCN2CCOCC2)C(=NC=N3)NC4=CC=C(C(=C4)Cl)F |
| InChI | InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| InChIKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Gefitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-445) |
Biological Description
| Alternative Names | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 123631 |
| Scientific Background | Gefitinib is a selective inhibitor of EGFR tyrosine kinase by blocking EGFR autophosphorylation. |
| References | 1. Ciardiello F., et al. (2000) Clin. Cancer Res. 6(5): 2053–2063. |
Product Images
Chemical structure of Gefitinib (SIH-445), a EGFR-Kinase inhibitor. CAS #: 184475-35-2. Molecular Formula: C22H24ClFN4O3. Molecular Weight: 446.9 g/mol.
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