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| Product Name | GW 441756 |
| Description |
NGFR kinase inhibitor |
| Purity | >99% |
| CAS No. | 504433-23-2 |
| Molecular Formula | C17H13N3O |
| Molecular Weight | 275.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 15 mM in DMSO |
| Source | Synthetic |
| Appearance | Red solid |
| SMILES | CN1C=C(C2=CC=CC=C21)/C=C3/C4=C(C=CC=N4)NC3=O |
| InChI | InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9- |
| InChIKey | NXNQLECPAXXYTR-LCYFTJDESA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | GW 441756 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-450) |
Biological Description
| Alternative Names | 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 9943465 |
| Scientific Background | GW 441756 is a potent and selective NGF receptor tyrosine kinase A (TrkA) inhibitor. Specifically, it is shown to block apoptosis and cell death induced by TrkA. GW-441756 displays > 100-fold selectivity over a range of other kinases. |
| References |
1. Wood E.R., et al. (2004) Bioorganic & Med. Chem. Ltr. 14(4): 953–957. 2. Jung E.J., Kim C.W., & Kim D.R. (2008) Exp. Mol. Med. 40(3): 276–285. |
Product Images
Chemical structure of GW 441756 (SIH-450), a NGFR kinase inhibitor. CAS #: 504433-23-2. Molecular Formula: C17H13N3O. Molecular Weight: 275.3 g/mol.
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