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| Product Name | H89 Dihydrochloride |
| Description |
PKA inhibitor |
| Purity | 99% (TLC) |
| CAS No. | 127243-85-0 |
| Molecular Formula | C20H22BrCl2N3O2S |
| Molecular Weight | 519.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml), methanol and 50% ethanol/water (20 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | C1=C(C2=C(C=C1)C=NC=C2)[S](NCCNCC=CC3=CC=C(Br)C=C3)(=O)=O |
| InChI | InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+ |
| InChIKey | ZKZXNDJNWUTGDK-NSCUHMNNSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | H89 Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-452) |
Biological Description
| Alternative Names | N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl |
| Research Areas | Cell Signaling |
| PubChem ID | 449241 |
| Scientific Background | H89 Dihydrochloride is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It has also been shown to inhibit CaM kinase II, casein kinase I and MYLK, as well as, Rsk-2, MSK1, Akt1, PKC µ, Rock-2, p70 S6 kinase α. H89 Dihydrochloride can induce apoptosis. It is cell permeable. |
| References |
1. Bouschet, T., (2003) J. Biol. Chem. 278(7): 4778–4785. 2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21. 3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105. |
Product Images
Chemical structure of H89 Dihydrochloride (SIH-452), a PKA inhibitor. CAS #: 127243-85-0. Molecular Formula: C20H22BrCl2N3O2S. Molecular Weight: 519.3 g/mol.
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