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| Product Name | JX 401 |
| Description |
p38 MAP kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 349087-34-9 |
| Molecular Formula | C21H25NO2S |
| Molecular Weight | 355.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3 |
| InChI | InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3 |
| InChIKey | OMGLGPKQUFSRNN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | JX 401 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-454) |
Biological Description
| Alternative Names | 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 1126109 |
| Scientific Background | JX 401 is a potent and reversible inhibitor of p38α. Specifically, it binds MAPK p38α. JX 401 is cell permeable. |
| References | 1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405. |
Product Images
Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol.
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