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| Product Name | NPC 15437 |
| Description |
PKC kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 141774-20-1 |
| Molecular Formula | C25H52Cl2N4O2 |
| Molecular Weight | 511.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in water, DMSO or methanol |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | O=C(N1C(CNC(=O)[C@@H](N)CCCCN)CCCC1)CCCCCCCCCCCC.Cl.Cl |
| InChI | InChI=1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1 |
| InChIKey | RISSBZWRJRRXTD-OLBPYZPGSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | NPC 15437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-464) |
Biological Description
| Alternative Names | (S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 16219723 |
| Scientific Background | NPC 15437 is selective inhibitor of protein kinase C (PKC). Specifically, it interacts with regulatory domain at residues 12-42. |
| References |
1. Sullivan J.P., Connor J.R., Shearer B.G., & Burch R.M. (1991) Agents and Actions. 34(1-2): 142–144. 2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123. |
Product Images
Chemical structure of NPC 15437 (SIH-464), a PKC kinase inhibitor. CAS #: 141774-20-1. Molecular Formula: C25H52Cl2N4O2. Molecular Weight: 511.6 g/mol.
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