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| Product Name | Midostaurin |
| Description |
Kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 120685-11-2 |
| Molecular Formula | C35H30N4O4 |
| Molecular Weight | 570.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | [N]48C1=C(C7=C(C2=C1[N](C3=CC=CC=C23)[C@@H]5O[C@]4([C@@]([C@@H]5N(C)C(=O)C6=CC=CC=C6)(OC)C)C)C(NC7)=O)C9=C8C=CC=C9 |
| InChI | InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,( |
| InChIKey | BMGQWWVMWDBQGC-PZFYLCKJSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Midostaurin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-468) |
Biological Description
| Alternative Names | 4’-N-Benzoyl-staurosporine, PKC-412, CGP 41251 |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 24202429 |
| Scientific Background | Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKCα, PKCβ and PKCγ isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis. |
| References |
1. Fabbro D., et al. (2000) Anti-Cancer Drug Design. 15(1): 17–28. 2. Odgerel, T., et al. (2008) Oncogene. 27(22): 3102–3110. 3. Bahlis, N.J., et al. (2005) Leukemia & Lymphoma. 46(6): 899–908. |
Product Images
Chemical structure of Midostaurin (SIH-468), a Protein kinase inhibitor (pan spec.). CAS #: 120685-11-2. Molecular Formula: C35H30N4O4. Molecular Weight: 570.6 g/mol.
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