SC 514

Name: SC 514
SKU: SIH-475
Availability: InStock

IKK-2 kinase inhibitor

Catalog No. SIH-475

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CAS No.	354812-17-2
Molecular Formula	C9H8N2OS2

SKU: SIH-475 Categories: Inhibitor, Small Molecules

Product Name	SC 514
Description	IKK-2 kinase inhibitor
Purity	>98% (TLC)
CAS No.	354812-17-2
Molecular Formula	C₉H₈N₂OS₂
Molecular Weight	224.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (>25 mg/ml)
Source	Synthetic
Appearance	Yellow solid
SMILES	C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
InChI	InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
InChIKey	BMUACLADCKCNKZ-UHFFFAOYSA-N
Safety Phrases	Classification: Acute toxicity, Oral (Category 3) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed Precautionary statements: P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician
Cite This Product	SC 514 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-475)

Alternative Names	4-Amino-[2',3'-bithiophene]-5-carboxamide
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	2807869
Scientific Background	SC 514 is a selective and reversible inhibitor of IκB kinase 2 / IKKβ (IKK-2). It has been shown to displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. SC-514 exhibits anti-inflammatory properties. SC 514 is cell permeable.
References	1. Kishore N., et al. (2003) J. Biol. Chem. 278(35): 32861–32871. 2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.

Chemical structure of SC 514 (SIH-475), a IKK-2 kinase inhibitor. CAS #: 354812-17-2. Molecular Formula: C9H8N2OS2. Molecular Weight: 224.3 g/mol.

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