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| Product Name | LH 846 |
| Description |
Casein kinase 1d inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 639052-78-1 |
| Molecular Formula | C16H13ClN2OS |
| Molecular Weight | 316.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White to beige powder |
| SMILES | CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3 |
| InChI | InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20) |
| InChIKey | DYHAMRNAHTWYKY-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4) Chronic aquatic toxicity(Category 4) Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H413 May cause long lasting harmful effects to aquatic life. |
| Cite This Product | LH 846 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-503) |
Biological Description
| Alternative Names | LH846, LH-846, N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide |
| Research Areas | Cell Signaling |
| PubChem ID | 851474 |
| Scientific Background | LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm. |
| References | 1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611. |
Product Images
Chemical structure of LH 846 (SIH-503), a Casein kinase 1d inhibitor. CAS #: 639052-78-1. Molecular Formula: C16H13ClN2OS. Molecular Weight: 316.8 g/mol.
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