Research Area

Phosphorylation

Phosphorylation is defined as the introduction of a phosphate group into an organic molecule. Phosphorylation has many functions including being an important regulator, activation of molecules, inhibiting protein activity, turning a nonpolar hydrophobic protein into a polar hydrophilic molecule and causing the binding of proteins to activate or inhibit particular cell signaling systems. Concomitantly, the process of de-phosphorylation (the removal of a phosphate group) plays a reciprocal and important role in the regulation of these functions too.

Phospho-specific antibodies are a powerful tool because of their ability to detect protein phosphorylation at very specific sites. This can lead to a highly specific analysis of what is occurring in the cell or cellular pathway under given experimental conditions. They are therefore critical reagents both for basic research and for clinical diagnosis.

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