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| Product Name | Okadaic acid |
| Description |
PP1 and PP2A inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 78111-17-8 |
| Molecular Formula | C44H68O13 |
| Molecular Weight | 805.0 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in chloroform, ethanol, methanol, acetone or ethyl acetate |
| Source | Synthetic |
| Appearance | White crystalline solid |
| SMILES | [C@@]45(OC3[C@H](O[C@H]([C@@H](O)C[C@@H](C2O[C@]1(OCCCC1)CC[C@H]2C)C)C([C@H]3O)=C)CC4)O[C@H](CC5)C=C[C@H]([C@H]7O[C@]6(O[C@@H](CC[C@H]6O)C[C@](O)(C)C(O)=O)C=C(C7)C)C |
| InChI | InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51 |
| InChIKey | QNDVLZJODHBUFM-WFXQOWMNSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 3), H311 Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled H315 Causes skin irritation Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P361 Remove/Take off immediately all contaminated clothing. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant |
| Cite This Product | Okadaic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-521) |
Biological Description
| Alternative Names | 9,10-Deepithio-9,10-didehydroacanthifolicin |
| Research Areas | Cell Signaling |
| PubChem ID | 446512 |
| Scientific Background | Okadaic acid is a potent and selective inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Okadaic acid is a naturally occurring polyether toxin that was originally derived from marine dinoflagellates, Prorocentrium spp.. It is a reversible inhibitor. |
| References | 1. Cohen P., Holmes C.F., & Tsukitani Y. (1990) Trends Biochem. 15(3): 98–102. |
Product Images
Chemical structure of Okadaic acid (SIH-521), a PP1 and PP2A inhibitor. CAS #: 78111-17-8. Molecular Formula: C44H68O13. Molecular Weight: 805 g/mol.
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