Taxol

Microtubule stabilizer

Catalog No. SIH-239

5 out of 5 based on 1 customer rating
CAS No. 33069-62-4
Molecular Formula C47H51NO14
SKU: SIH-239 Categories: ,

Clear
SIH-239_Taxol_Chemical_Structure.png
Product Name Taxol
Description

Microtubule stabilizer

Purity >98% (TLC); NMR (Conforms)
CAS No. 33069-62-4
Molecular Formula C47H51NO14
Molecular Weight 853.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble in DMSO, ethanol or acetonitrile
Source Synthetic
Appearance White solid
SMILES CC1=C2[C@@]([C@]([C@H]([C@@H]3[C@]4([C@H](OC4)C[C@@H]([C@]3(C(=O)[C@@H]2OC(=O)C)C)O)OC(=O)C)OC(=O)C5=CC=CC=C5)(C[C@@H]1OC(=O)[C@H](O)[C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)(C)C
InChI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-
InChIKey RCINICONZNJXQF-MZXODVADSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
R68- Possible risk of irreversible effects
Hazard Phrases:
H318-H361f-H341-H332-H312-H302-H335-H315-H334-H317
Precautionary Phrases:
P280-P305+P351+P338-P260-P261-P342+P311
Cite This Product Taxol (StressMarq Biosciences, Canada, Cat # SIH-239)

Biological Description

Alternative Names (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Paclitaxel
Research Areas Apoptosis, Cancer
PubChem ID 36314
Scientific Background Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2).
References 1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327.
2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067.

Product Images

<p>Chemical structure of Taxol (SIH-239), a Microtubule stabilizing agent. CAS #: 33069-62-6. Molecular Formula: C47H51NO14. Molecular Weight: 853.9 g/mol.</p>

Chemical structure of Taxol (SIH-239), a Microtubule stabilizing agent. CAS #: 33069-62-6. Molecular Formula: C47H51NO14. Molecular Weight: 853.9 g/mol.

Reviews

1 review for Taxol

  1. 5 out of 5

    :

    Based on validation through cited publications.

Add a review

Your email address will not be published. Required fields are marked *