JG-48

Heat Shock Protein 70/HSP70 Modulator

Molecular Formula: C₂₀H₁₆F₃N₃OS₂

Molecular Weight: 435.48 g/mol

Research Areas: Cancer Research, Heat Shock, Neuroscience, Neurodegeneration

 

Alternative Names: (2Z,5E)-3-ethyl-5-(3-methyl-6-(trifluoromethyl)benzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-2-ylmethylene)thiazolidin-4-one

 

Biological Description

JG-48 reduces both phosphorylated and total tau in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells. The reduction of tau depends on Hsp70 and the proteasome. JG-48 also recovers long-term potentiation deficits in brain slices from rTg4510 mice.