MKT-077

Heat Shock Protein 70/HSP70 Inhibitor

CAS Number: 147366-41-4

Molecular Formula: C₂₁H₂₂ClN₃OS₂

Molecular Weight: 432 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis

 

Alternative Names: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride, FJ-776

 

Biological Description

MKT-077 is an allosteric Hsp70 inhibitor. It binds within Hsp70’s nucleotide binding domain, adjacent to ATP/ADP binding pocket. MKT-077 inhibits J-stimulated ATP turnover rate, reduces pathogenic tau levels in HeLa and neuroblastoma cells and has anti-cancer activity, with EC50 values of 1 uM against MCF-7 and MDA-MB-231 breast cancer cells. MKT-077 binds to Hsc70 and mtHsp70 (mortalin or GRP75) in cells.