At StressMarq we are dedicated to driving research forward through partnerships across many avenues and disciplines.

We received a request for information from a prominent scientist in the field of oxidative stress, Dov Lichtenberg, Ph.D. He is interested in collaborating with researchers who are measuring oxidative stress using various biomarkers in the hopes of identifying different types of oxidative stress.

If you are interested in collaborating please read his request and contact him directly using the contact information provided below.

Request for Information

This letter relates to the long list of Oxidative Stress (OS) products (mostly kits) offered by StressMarq Biosciences Inc.. As you probably realize, the term OS is intuitively defined and the OS level, as evaluated by different criteria, correlate with each other only when the methods relate to similar biomarkers (Dotan et. al., 2004). As an example, the level of OS, as evaluated by various methods of analysis of lipid peroxidation products, yields reasonable correlations with each other. The same is true for the OS values determined on the basis of the activities of antioxidative enzymes, but no correlation has been observed between OS, as evaluated by methods based on lipid peroxidation and OS, as evaluated on the basis of the level of an antioxidative enzyme.

Hence, OS cannot be defined by a universal criterion, as discussed in our recent BBRC mini-review (Lichtenberg and Pinchuk, 2015). The question remains whether the lack of correlation between the estimates of OS based on different methods (e.g. different kits) do not correlate with each other because they are different manifestations of the same factor (OS) or because there are different “types” of OS that interact differently with different biomarkers.

Identifying different types of OS requires much more information than we presently have. One sort of data that may help solving this question problem is the correlation (or lack of) between the OS, as evaluated by different methods. These include results of data obtained by using kits based on determination of the level of DNA fragmentation products (e.g. 8OHdG), kits based on antibodies for nitrotyrosine, kits made to assay the levels of proteins of importance in redox biology (e.g. HO-1) and kits based on assaying the level of stabilized radical species. If you have such data, either yours or/and published, I’ll be grateful to you if you can share it with me (preferably by returned e-mail).

All I can give you in return is my promise to use the data only for curiosity-driven research, a due credit for data that I hope to use for (joint?) publications and my sincere thanks.

Looking forward to your response,

Sincerely yours,

Dov

Dov Lichtenberg, Ph.D.
Emeritus Professor of Pharmacology,
Department of Physiology and Pharmacology,
Tel Aviv University,
Sackler Faculty of Medicine,
Tel Aviv 69978, Israel
Phone: +972-3-6407305
E-mail:   physidov@post.tau.ac.il

University Profile: https://en-med.tau.ac.il/profile/physidov
University website: www.tau.ac.il/~physidov
Research Gate (Publication list): https://www.researchgate.net/profile/Dov_Lichtenberg