StressMarq Biosciences has developed an extensive range of fibrillar, oligomeric and monomeric protein preparations for use in neurodegenerative disease research including alpha synuclein, beta synuclein, gamma synuclein, tau, amyloid beta, SOD1 and TTR. Our goal is to be the world leader in the development and supply of active, pathology-inducing protein aggregates to assist scientists with disease model development and accelerate neurodegenerative disease drug discovery.

Beta synuclein, like alpha synuclein, is found in presynaptic nerve terminals. It is believed to play a role in maintaining vesicular membrane curvature¹ and does not aggregate under physiological conditions.² Wild-type beta synuclein inhibits the aggregation of alpha synuclein³ and mutant (V70M and P123H) beta synuclein has been associated with Dementia with Lewy Bodies (DLB).⁴  Human beta synuclein PFFs do not induce endogenous alpha synuclein aggregation in primary rat hippocampal neurons, meaning they could be useful as a control in alpha synuclein experiments.

StressMarq manufactures wild-type beta synuclein fibrils and monomers for use in neurodegenerative disease research.

• Human Recombinant Beta Synuclein Pre-formed Fibrils (PFFs) | catalog# SPR-457
• Human Recombinant Beta Synuclein Monomers | catalog# SPR-405

TEM of Human Recombinant Beta Synuclein Pre-formed Fibrils (catalog# SPR-457)

Primary rat hippocampal neurons treated with human beta synuclein pre-formed fibrils (SPR-457) do not show Lewy body inclusion formation. Fibrils were sonicated 1 hour and added at 1 ug/mL concentration. A) Hoechst. B) pSer129. C) Merge.

1. Westphal, C.H., Chandra, S.S. (2013). J Biol Chem. 288(3):1829-40.
2. Yamin, F. et al. (2005) Biochemistry. 44, 9096-9107.
3. Hashimoto, M. et al. (2001) Neuron. 32,213-223.
4. Ohtake, H. et al. (2004). Neurology. 63(5):805-11

Product Citations

StressMarq’s proteins for neurodegenerative disease research have been cited in many peer-reviewed scientific journals. 

• Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease. Mao, H. et al. Transl Neurodegener. Jul 2024.
  • Catalog# SPR-457: Human Recombinant Beta Synuclein Pre-formed Fibrils (Type 1)

Supplemental Learning Materials

Technical Support Resources

• Handling Instructions | Synucleins
• Protocols | Neuro Proteins
• Sonication Protocol | PFFs
• Frequently Asked Questions | Neuro Proteins

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