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| Product Name | Amifostine |
| Description |
HIF-1α activator |
| Purity | >98% |
| CAS No. | 20537-88-6 |
| Molecular Formula | C5H15N2O3PS |
| Molecular Weight | 214.22 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C(CN)CNCCSP(=O)(O)O |
| InChI | InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) |
| InChIKey | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | Amifostine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-210) |
Biological Description
| Alternative Names | S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 2141 |
| Scientific Background | Amifostine is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy. Inside cells it detoxifies reactive metabolites of platinum and alkylating agents (1, 2). Other effects include accelerated DNA repair (1), induction of cellular hypoxia (1), inhibition of apoptosis (2), alteration of gene expression (2) and modification of enzyme activity (2). |
| References |
1. Kouvaris J.R., Kouloulias V.E., Blahos L.J. (2007) Oncologist. 12(6): 738-747. 2. Amifostine: BC Cancer Agency. 2006-03-01. |
Product Images
Chemical structure of Amifostine (SIH-210), a Cellular protectant. CAS #: 20537-88-6. Molecular Formula: C5H15N2O3PS. Molecular Weight: 214.22 g/mol.
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