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| Product Name | Aclacinomycin A |
| Description |
Proteasome inhibitor |
| Purity | >98% |
| CAS No. | 57576-44-0 |
| Molecular Formula | C42H53NO15 |
| Molecular Weight | 811.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 30 mg/ml DMSO or DMF |
| Source | Synthetic |
| Appearance | Yellow-Orange Solid |
| SMILES | CC[C@]1(C[C@@H](C2=C(C3=C(C=C2[C@H]1C(=O)OC)C(=O)C4=C(C3=O)C(=CC=C4)O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O[C@H]7CCC(=O)[C@@H](O7)C)O)N(C)C)O |
| InChI | InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18( |
| InChIKey | USZYSDMBJDPRIF-SVEJIMAYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Aclacinomycin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-335) |
Biological Description
| Alternative Names | Methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-?-L-lyxo-hexopyranosyl}-3-(dimethylamino)-?-L-lyx o-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydro-1-tetracenecarboxylate, Aclarubicin |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors |
| PubChem ID | 451415 |
| Scientific Background | Specific inhibitor of the 20S proteasome chymotrypsin-like activity. Antitumor agent. Cell permeable. |
| References | 1. Figueiroda-Pereira M.E., et al. (1996) J. Biol. Chem. 271:16455. |
Product Images
Chemical structure of Aclacinomycin A (SIH-335), a Proteasome inhibitor. CAS #: 57576-44-0. Molecular Formula: C42H53NO15. Molecular Weight: 811.9 g/mol.
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