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| Product Name | 115-7C |
| Description |
Hsp70 Activator |
| Purity | >98% |
| Molecular Formula | C23H22Cl2N2O5 |
| Molecular Weight | 477.34 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in DMSO (20 mg/ml) |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CC1=C(C(NC(=O)N1CCCC(=O)O)c2ccc(cc2Cl)Cl)C(=O)OCc3ccccc3 |
| InChI | InChI=1S/C23H22Cl2N2O5/c1-14-20(22(30)32-13-15-6-3-2-4-7-15)21(17-10-9-16(24)12-18(17)25)26-23(31)27(14)11-5-8-19(28)29/h2-4,6-7,9-10,12,21H,5,8,11,13H2,1H3,(H,26,31)(H,28,29) |
| InChIKey | UHBVLBSCOSTTAV-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | 115-7C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-123) |
Biological Description
| Alternative Names | 4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2 |
| Research Areas | Cancer, Heat Shock |
| Scientific Background | 115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02. |
| References |
1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486 |
Product Images
Chemical structure of 115-7C (SIH-123), a Hsp70 Activator. Molecular Formula: C₂₃H₂₂Cl₂N₂O₅. Molecular Weight: 477.34 g/mol.
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Based on validation through cited publications.