C-Dim 12

Displays neuroprotective activity in a mouse model of progressive neurodegeneration

Catalog No. SIH-616

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CAS No. 178946-89-9
Molecular Formula C23H17ClN2
SKU: SIH-616 Categories: ,

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SIH-616-C-Dim-12-Chemical-Structure.png
Product Name C-Dim 12
Description

Displays neuroprotective activity in a mouse model of progressive neurodegeneration

Purity >98% (TLC); NMR (Conforms)
CAS No. 178946-89-9
Molecular Formula C23H17ClN2
Molecular Weight 356.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Activator
Solubility May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml)
Source Synthetic
Appearance Orange powder
SMILES ClC(C=C1)=CC=C1C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5
InChI 1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
InChIKey LTLRXTDMXOFBDW-UHFFFAOYSA-N
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product C-Dim 12 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-616)

Biological Description

Alternative Names 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Research Areas Cell Signaling, Epigenetics and Nuclear Signaling, Neurodegeneration, Neuroscience, NFkB Pathway, Nuclear Signaling Pathways
PubChem ID 5302583
Scientific Background C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4).
References 1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:3825
2.Li X., et al. (2012) Biochem. Pharmacol. 83:1445
3.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:1021
4.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125

Product Images

<p>Chemical structure of C-Dim 12 (SIH-616), a Displays neuroprotective activity in a mouse model of progressive neurodegeneration. CAS #: 178946-89-9. Molecular Formula: C23H17ClN2. Molecular Weight: 356.9 g/mol.</p>

Chemical structure of C-Dim 12 (SIH-616), a Displays neuroprotective activity in a mouse model of progressive neurodegeneration. CAS #: 178946-89-9. Molecular Formula: C23H17ClN2. Molecular Weight: 356.9 g/mol.

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