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| Product Name | C-Dim 12 |
| Description |
Displays neuroprotective activity in a mouse model of progressive neurodegeneration |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 178946-89-9 |
| Molecular Formula | C23H17ClN2 |
| Molecular Weight | 356.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (35 mg/ml); or ethanol (35 mg/ml) |
| Source | Synthetic |
| Appearance | Orange powder |
| SMILES | ClC(C=C1)=CC=C1C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5 |
| InChI | 1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H |
| InChIKey | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | C-Dim 12 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-616) |
Biological Description
| Alternative Names | 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole] |
| Research Areas | Cell Signaling, Epigenetics and Nuclear Signaling, Neurodegeneration, Neuroscience, NFkB Pathway, Nuclear Signaling Pathways |
| PubChem ID | 5302583 |
| Scientific Background | C-DIM 12 is a nurr1 activator that inhibits bladder cancer growth (1,2). It also inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters (3). It displays neuroprotective activity in a mouse Parkinson's disease models (4). |
| References |
1.Inamoto T., et al. (2008) Mol. Cancer Ther. 7:3825 2.Li X., et al. (2012) Biochem. Pharmacol. 83:1445 3.De Miranda B.R.,et al. (2015) Mol. Pharmacol. 87:1021 4.De Miranda B.R., et al. (2013) J. Pharmacol. Exp. Ther. 345:125 |
Product Images
Chemical structure of C-Dim 12 (SIH-616), a Displays neuroprotective activity in a mouse model of progressive neurodegeneration. CAS #: 178946-89-9. Molecular Formula: C23H17ClN2. Molecular Weight: 356.9 g/mol.
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