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| Product Name | Dibutyryl-cAMP |
| Description |
Activates PKA |
| Purity | ≥97% (HPLC); NMR (Conforms) |
| CAS No. | 16980-89-5 |
| Molecular Formula | C18H23N5O8P • Na |
| Molecular Weight | 491.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (50 mg/ml); water (50 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white powder |
| SMILES | CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+] |
| InChI | InChI=1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15 |
| InChIKey | KRBZRVBLIUDQNG-JBVYASIDSA-M |
| Safety Phrases | No hazard pictogram, no signal word, no hazard statement(s), no precautionary statement(s) required |
| Cite This Product | Dibutyryl-cAMP (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-632) |
Biological Description
| Alternative Names | N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt; Bucladesine Na |
| Research Areas | Cell Signaling, Neuroscience, Neurotransmission, Protein Phosphorylation, Serine / Threonine Kinases, Stem Cells, Neural Stem Cells, PKA |
| PubChem ID | 23663967 |
| Scientific Background | Cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells (1). Activates PKA (2,3). Induces morphological differentiation of astrocytes (4). Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents) (5). |
| References |
1.,M Bartsch et al. Biol. Chem. 2003 384:1321 2.,ML Carranza et al. J. Physiol. 1998 15:511 3.,YJ Hei et al. Mol. Pharmacol. 1991 39:233 4.,M Imamura et al. Proc. Natl. Acad. Sci. USA 1998 95:6139 5.,N Xia et al. Sci. Rep. 2016 6:20270 |
Product Images
Chemical structure of Dibutyryl-cAMP (SIH-632), a Activates PKA. CAS #: 16980-89-5. Molecular Formula: C18H23N5O8P • Na. Molecular Weight: 491.4 g/mol.
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