AG490

Name: AG490
SKU: SIH-428
Availability: InStock

JAK-2 kinase inhibitor

Catalog No. SIH-428

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CAS No.	133550-30-8
Molecular Formula	C17H14N2O3

SKU: SIH-428 Categories: Inhibitor, Small Molecules

Product Name	AG490
Description	JAK-2 kinase inhibitor
Purity	>98% (TLC)
CAS No.	133550-30-8
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Source	Synthetic
Appearance	Tan solid
SMILES	C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
InChI	InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKey	TUCIOBMMDDOEMM-RIYZIHGNSA-N
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up.
Cite This Product	AG490 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-428)

Alternative Names	Tyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	5328779
Scientific Background	AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
References	1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828. 3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.

Chemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol.

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