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| Product Name | Adiporon |
| Description |
Adiponectin receptor agonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 924416-43-3 |
| Molecular Formula | C27H28N2O3 |
| Molecular Weight | 428.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (40 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | White crystalline powder |
| SMILES | N2(CCC(CC2)NC(=O)COc3ccc(cc3)C(=O)c4ccccc4)Cc1ccccc1 |
| InChI | InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30) |
| InChIKey | SHHUPGSHGSNPDB-UHFFFAOYSA-N |
| Safety Phrases | Not a hazardous substance or mixture. |
| Cite This Product | Adiporon (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-635) |
Biological Description
| Alternative Names | 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide |
| Research Areas | Alzheimer's Disease, Atherosclerosis, Cardiovascular System, Diabetes Associated, Neurodegeneration, Neuroscience, Oxidative Stress, Tangles & Tau |
| PubChem ID | 16307093 |
| Scientific Background | A novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 M respectively (1). Displayed similar effects to adiponectin in muscle and liver such as activation of PPAR and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet (1,2). Attenuates post-ischemic myocardial apoptosis and oxidative stress and improves cardiac function in a mouse model of myocardial ischemia/reperfusion injury (3). Active in vivo. It has been shown that it clears neruofibrillary tangles and rescues neuronal tauopathy- associated defects (4). |
| References |
1. M Okada-Iwabu et al. (2013) Nature. 503:493 2. S Lee and HB Kwak (2014)J. Exerc. Rehabil. 10:54 3. Y Zhang et al. (2015) Am. J. Physiol. Endocrinol. Metab. 309:E275. 4. E.R. McGregor et al. (2025) Comm Biol. 8 : https://www.nature.com/articles/s42003-024-07391-z |
Product Images
Chemical structure of Adiporon (SIH-635), a Adiponectin Receptor Agonist. CAS #: 924416-43-3. Molecular Formula: C27H28N2O3. Molecular Weight: 428.5 g/mol.
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