Discovery through Partnership | Excellence through Quality
| Product Name | Rosiglitazone Maleate |
| Description |
Insulin sensitizer |
| Purity | >98% |
| CAS No. | 155141-29-0 |
| Molecular Formula | C18H19N3O3S•C4H4O4 |
| Molecular Weight | 473.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | Soluble in DMSO (3 mg/ml) or DMF (10 mg/ml) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | C2=C(CC1SC(=O)NC1=O)C=CC(=C2)OCCN(C3=CC=CC=N3)C.O=C(O)C=C/C(=O)O |
| InChI | InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) |
| InChIKey | YASAKCUCGLMORW-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Rosiglitazone Maleate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-379) |
Biological Description
| Alternative Names | 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Research Areas | Cell Signaling |
| PubChem ID | 77999 |
| Scientific Background | Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is anti-diabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin. |
| References |
1. Werner A.L., & Travaglini M.T. (2001) Pharmacotherapy. 21(9): 1082-99. 2. McMorran M., and Vu D. (2001) CMAJ. 165(1): 82-3, 86-7. 3. Malinowski J.M. & Bolesta S. (2000) Clin. Ther. 22(10): 1151-68. 4. Cheng-Lai A., & Levine A. (2000) Heart Dis. 2(4): 326-33. 5. Knock G.A., et al. (1999) Eur. J. Pharmacol. 368(1): 103-9. 6. Balfour J.A., & Plosker G.L. (1999) Drugs. 57(6): 921-30. 7. Parks D.J., et al. (1998) Bioorg. Med. Chem. Lett. 8(24): 3657-8. |
Product Images
Chemical structure of Rosiglitazone Maleate (SIH-379), a Insulin sensitizing agent. CAS #: 122320-73-4. Molecular Formula: C18H19N3O3S. Molecular Weight: 357.4 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.