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| Product Name | Ketanserin tartrate |
| Description |
Serotonin 5HT2A Antagonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 83846-83-7 |
| Molecular Formula | C22H22FN3O3 • C4H6O6 |
| Molecular Weight | 545.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | May be dissolved in DMSO (30 mg/ml); or Water (5 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O.C(C(C(=O)O)O)(C(=O)O)O |
| InChI | InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10) |
| InChIKey | KMTLTEVOQLMYRS-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements: H301 Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501 |
| Cite This Product | Ketanserin tartrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-618) |
Biological Description
| Alternative Names | 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione, tartrate; R41468 |
| Research Areas | Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter Receptors, Potassium Channels |
| PubChem ID | 135348 |
| Scientific Background | Ketanserin tartrate is a selective antagonist of the serotonin 5-HT2A receptor, with additional affinity for the 5-HT1Dα receptor. While primarily studied for its cardiovascular effects, including treatment of hypertension post-coronary artery surgery, Ketanserin has gained attention in neuroscience for its ability to modulate serotonergic signaling. It has been used to investigate the cognitive and perceptual effects of 5-HT2A receptor activation, including disruption of hallucinogenic responses. Its role in modulating serotonin pathways makes it a valuable tool in neuropsychiatric and neuropharmacological research. |
| References |
1. Leysen JE., et al. (1981) Life Sci. 28:1015. 2. Zgombick JM., et al. (1995) Eur. J. Pharmacol. 291:9. 3. Vandenbroucke G., et al.(1994) J. Cardiothorac. Vasc. Anesth. 8: P324. 4. Quednow BB.,et al. (2012) Neuropsychopharmacology. 37:630. |
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