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| Product Name | Ketanserin tartrate |
| Description |
Serotonin 5HT2A Antagonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 83846-83-7 |
| Molecular Formula | C22H22FN3O3 • C4H6O6 |
| Molecular Weight | 545.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | May be dissolved in DMSO (30 mg/ml); or Water (5 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O.C(C(C(=O)O)O)(C(=O)O)O |
| InChI | InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10) |
| InChIKey | KMTLTEVOQLMYRS-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements: H301 Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501 |
| Cite This Product | Ketanserin tartrate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-618) |
Biological Description
| Alternative Names | 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione, tartrate; R41468 |
| Research Areas | Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter Receptors, Potassium Channels |
| PubChem ID | 135348 |
| Scientific Background | A selective serotonin 5-HT2A receptor antagonist (IC50 = 6.3 nM) (1). Also exhibits significant selectivity for the human 5-HT1Dα receptor (2). Was shown to be effective for the treatment of hypertension following coronary artery surgery (3). It has been used to disrupt the hallucinogenic effects of psilocybin and to explore cognitive effects of the 5-HT2A receptor (4). |
| References |
1. Leysen JE., et al. (1981) Life Sci. 28:1015. 2. Zgombick JM., et al. (1995) Eur. J. Pharmacol. 291:9. 3. Vandenbroucke G., et al.(1994) J. Cardiothorac. Vasc. Anesth. 8: P324. 4. Quednow BB.,et al. (2012) Neuropsychopharmacology. 37:630. |
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