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| Product Name | Nalmefene HCl |
| Description |
Opioid Receptor Antagonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 58895-64-0 |
| Molecular Formula | C21H25NO3 • HCl |
| Molecular Weight | 375.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | May be dissolved in water (25 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl |
| InChI | InChI=1S/C21H25NO3.ClH/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13;/h4-5,13,16,19,23-24H,1-3,6-11H2;1H/t16-,19+,20+,21-;/m1./s1 |
| InChIKey | GYWMRGWFQPSQLK-OPHZJPRHSA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements: H301 - H336 - H410 Precautionary Statements: P261 - P264 - P270 - P271 - P273 - P301 + P310 |
| Cite This Product | Nalmefene HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-621) |
Biological Description
| Alternative Names | (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylene-morphinan-3,14-diol, hydrochloride |
| PubChem ID | 5388881 |
| Scientific Background | An opiod antagonist with a very similar activity profile to naloxone, however, it displays slower onset and longer duration of action (1). It antagonizes the effects of salvinorin (2) (delta-agonist) as well as herkinorin (3) (mu-agonist). Has been used as a therapeutic for treatment of alcohol dependence (4). |
| References |
1.Osborn, M.D., et al. (201) Life Sci. 86:624. 2. Butelman E.R., et al. (2009) J. Pharmacol. Exp. Ther. 328:588. 3.Butelman E.R., et al. (2008) J. Pharmacol. Exp. Ther. 327:154. 4.Soyka M., and Rosner S. (2008) Curr. Drug Abuse Rev. 1:280. |
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