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| Product Name | AS 041164 |
| Description |
PI 3-Kgamma kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 6318-41-8 |
| Molecular Formula | C11H7NO4S |
| Molecular Weight | 249.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml). For in vivo administration this compound was suspended in 0.5% carboxymethylcellulose/0.25% Tween 20 as a vehicle |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C2=C(C=C1/C(NC(S1)=O)=O)C=CC3=C2OCO3 |
| InChI | InChI=1S/C11H7NO4S/c13-10-9(17-11(14)12-10)4-6-1-2-7-8(3-6)16-5-15-7/h1-4H,5H2,(H,12,13,14) |
| InChIKey | SDGWAUUPHUBJNQ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AS 041164 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-433) |
Biological Description
| Alternative Names | NSC31098, 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 233033 |
| Scientific Background | AS 041164 is a selective PI 3-Kγ isoform inhibitor. It also blocks neutrophil migration. |
| References | 1. Ferrandi C., et al. (2007) J. Pharmacol. Exp.Ther. 322(3): 923–930. |
Product Images
Chemical structure of AS 041164 (SIH-433), a PI 3-Kgamma kinase inhibitor. CAS #: 6318-41-8. Molecular Formula: C11H7NO4S. Molecular Weight: 249.2 g/mol.
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