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| Product Name | AZD6244 |
| Description |
ERK kinase inhibitor |
| Purity | >98% |
| CAS No. | 606143-52-6 |
| Molecular Formula | C17H15BrClFN4O3 |
| Molecular Weight | 457.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (92 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| InChI | InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChIKey | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H318: Causes serious eye damage. H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure. Precautionary statements: P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P302+352: IF ON SKIN: Wash with plenty of soap and water. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell. |
| Cite This Product | AZD6244 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-495) |
Biological Description
| Alternative Names | Selumetinib, AZD6244, 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 10127622 |
| Scientific Background | AZD6244 is a MEK-1 inhibitor. Specifically, AZD6244 inactivates the phosphorylation of ERK1/2. |
| References | 1. Haasbach E., Hartmayer C., & Planz O. (2013) Antiviral Research. 98(2): 319–324. |
Product Images
Chemical structure of AZD6244 (SIH-495), a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol.
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