CBA

Name: CBA
SKU: SIH-633
Availability: InStock

TRPM4 channel blocker

Catalog No. SIH-633

0 out of 5 based on 0 customer ratings

Reviews (0) | Datasheet

CAS No.	351424-20-9
Molecular Formula	C15H11Cl2NO4

SKU: SIH-633 Categories: Blocker, Small Molecules

Product Name	CBA
Description	TRPM4 channel blocker
Purity	>98% (TLC); NMR (Conforms)
CAS No.	351424-20-9
Molecular Formula	C₁₅H₁₁Cl₂NO₄
Molecular Weight	340.2
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Blocker
Solubility	May be dissolved in DMSO (35 mg/ml)
Source	Synthetic
Appearance	Off-white powder
SMILES	C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl
InChI	InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21)
InChIKey	CVQCJPCMPGKEDH-UHFFFAOYSA-N
Safety Phrases	Not a hazardous substance or mixture.
Cite This Product	CBA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-633)

Alternative Names	4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5
Research Areas	Ion Channels, Neuroscience, Neurotransmission, Transient Receptor Potential (TRP) Channels
PubChem ID	2264067
Scientific Background	CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 M) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors (1). Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration (2). A highly useful tool for exploring the functions of TRM4 in a variety of cell types (3,4).
References	1.,LC Ozhathil et al. Br. J. Pharmacol. 2018 175:2504 2.,B Bianchi et al. Mol. Brain 2018 11:41 3.,A Borgstrom et al. J. Mol. Biol. 2021 433:166665 4.,G Diszhazi et al. J. Biol. Chem. 2021 297:101015

Chemical structure of CBA (SIH-633), a TRPM4 channel blocker. CAS #: 351424-20-9. Molecular Formula: C15H11Cl2NO4. Molecular Weight: 340.2 g/mol.

There are no reviews yet.

Be the first to review “CBA”