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| Product Name | ML133 HCl |
| Description |
Potassium channel Blocker- Neuroprotective |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 1222781-70-5 |
| Molecular Formula | C19H19NO • HCl |
| Molecular Weight | 313.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Blocker |
| Solubility | May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl |
| InChI | 1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H |
| InChIKey | NGQIBUUFXDPHKT-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements: H302 - H315 - H318 - H335 - H400 Precautionary Statements: P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Cite This Product | ML133 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-617) |
Biological Description
| Alternative Names | N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine, hydrochloride |
| Research Areas | Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter Receptors, Potassium Channels |
| PubChem ID | 44247466 |
| Scientific Background | A potent and selective blocker of the inwardly rectifying Kir2 potassium channel, IC50s = 1.8, 2.8, 2,9, and 4.0 µM for Kir2.1, Kir2.6, Kir2.2, and Kir2.3, respectively (1). Intrathecal injection of ML133 attenuated the proliferation of microglia and neuropathic pain behaviors after nerve injury (2). ML133 inhibits microglial priming pointing to Kir2.1 channels as a new therapeutic target for neuronal damage (3). Moreover, treatment with ML133 one hour post-injury was sufficient to improve neuronal survival in a traumatic brain injury human organoid model (4). |
| References |
1. Wang H.R. et al. 2011. ACS Chem. Biol. 6:845. 2. Gattlen C. et al. (2020) Glia 68:2119. 3. Spencer N.G. et al. (2016) PLoS One. 11(9):e0162497. 4. Lai J.D. et al. 2024. Cell Stem Cell 31:519. |
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