Muscone

Antiinflammatory and Neuroprotective activity

Catalog No. SIH-612

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CAS No. 541-91-3
Molecular Formula C16H30O
SKU: SIH-612 Categories: ,

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SIH-612-Muscone-Chemical-Structure.png
Product Name Muscone
Description

Antiinflammatory and Neuroprotective activity

Purity >98% (TLC); NMR (Conforms)
CAS No. 541-91-3
Molecular Formula C16H30O
Molecular Weight 238.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Blocker
Solubility May be dissolved in DMSO (35 mg/ml); or Ethanol (35 mg/ml)
Source Synthetic
Appearance Colorless oil
SMILES CC1CCCCCCCCCCCCC(=O)C1  
InChI InChI=1S/C16H30O/c1-15-12-10-8-6-4-2-3-5-7-9-11-13-16(17)14-15/h15H,2-14H2,1H3  
InChIKey ALHUZKCOMYUFRB-UHFFFAOYSA-N  
Safety Phrases GHS Hazard Statements: Not Classified
Cite This Product Muscone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-612)

Biological Description

Alternative Names 3-Methyl-cyclopentadecanone (racemic)
Research Areas Angiogenesis, Cardiovascular System
PubChem ID 10947
Scientific Background Muscone is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes(1). It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy (2) and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway (3). In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury (4) and improves cardiac function in mice after myocardial infarction (5) via enhancement of angiogenesis (6).
References 1. Ahmed L., et al. (2018) Proc. Acad. Natl. Sci. USA. 115:E3950
2. Zhou L.Y., et al. (2020) J. Neurochem. 155:154
3. Yu S., et al. (2020) Int. Immunopharmacol. 82:106355
4. Wei C.J., et al. (2021) J. Biol. Regul. Homeost. Agents. 35:85
5. Du Y., et al. (2018) Am. J. Transl. Res. 10:4235
6. Du Y., et al. (2018) Med. Sci. Monit. 24:8870

Product Images

<p>Chemical structure of Muscone (SIH-612), a Antiinflammatory and Neuroprotective activity. CAS #: 541-91-3. Molecular Formula: C16H30O. Molecular Weight: 238.4 g/mol.</p>

Chemical structure of Muscone (SIH-612), a Antiinflammatory and Neuroprotective activity. CAS #: 541-91-3. Molecular Formula: C16H30O. Molecular Weight: 238.4 g/mol.

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