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| Product Name | Brefeldin A |
| Description |
GEF inhibitor |
| Purity | >98% |
| CAS No. | 20350-15-6 |
| Molecular Formula | C16H24O4 |
| Molecular Weight | 280.36 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Appearance | White Crystalline Solid |
| SMILES | C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C/C(=O)O1)O)O |
| InChI | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+, |
| InChIKey | KQNZDYYTLMIZCT-PNFJWZTBSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310 |
| Cite This Product | Brefeldin A (StressMarq Biosciences, Canada, Cat # SIH-225) |
Biological Description
| Alternative Names | Cyanaein |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5287620 |
| Scientific Background | Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2). |
| References |
1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108. |
Product Images
Chemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol.
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Based on validation through cited publications.