C-646

Name: C-646
SKU: SIH-350
Availability: InStock

HAT inhibitor

Catalog No. SIH-350

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CAS No.	328968-36-1
Molecular Formula	C24H19N3O6

SKU: SIH-350 Categories: Inhibitor, Small Molecules

Product Name	C-646
Description	HAT inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	328968-36-1
Molecular Formula	C₂₄H₁₉N₃O₆
Molecular Weight	445.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 10 mg/ml DMSO
Source	Synthetic
Appearance	Orange Solid
SMILES	CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)/C=C/3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C
InChI	InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+
InChIKey	HEKJYZZSCQBJGB-XDHOZWIPSA-N
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Cite This Product	C-646 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-350)

Alternative Names	4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid
Research Areas	Cell Signaling
PubChem ID	1285940
Scientific Background	Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable.
References	1. Bowers E.M., et al. (2010) Chem. Biol. 17: 471. 2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644. 3. Marek R., et al. (2011) J. Neurosci. 31: 7486. 4. Min S.W., et al. (2010) Neuron 67: 953.

Chemical structure of C-646 (SIH-350), a HAT inhibitor. CAS #: 328968-36-1. Molecular Formula: C24H19N3O6. Molecular Weight: 445.4 g/mol.

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